Reduced intravenous glutathione in the treatment of early Parkinson's disease

By Sechi G; Deledda MG; Bua G; Satta WM; Deiana GA; Pes GM; Rosati G

Address: Department of Neurology, University of Sassari, Italy
Source: Prog Neuropsychopharmacol Biol Psychiatry, 20(7):1159-70 1996 Oct
Abstract

Several studies have demonstrated a deficiency in reduced glutathione (GSH) in the nigra of patients with Parkinson's Disease (PD). In particular, the magnitude of reduction in GSH seems to parallel the severity of the disease. This finding may indicate a means by which the nigra cells could be therapeutically supported. 2. The authors studied the effects of GSH in nine patients with early, untreated PD. GSH was administered intravenous, 600 mg twice daily, for 30 days, in an open label fashion. Then, the drug was discontinued and a follow-up examination carried-out at 1-month interval for 2-4 months. Thereafter, the patients were treated with carbidopa-levodopa. 3. The clinical disability was assessed by using two different rating scale and the Webster Step-Second Test at baseline and at 1-month interval for 4-6 months. All patients improved significantly after GSH therapy, with a 42% decline in disability. Once GSH was stopped the therapeutic effect lasted for 2-4 months. 4. Our data indicate that in untreated PD patients GSH has symptomatic efficacy and possibly retards the progression of the disease.

Publication Type: Clinical Trial; Journal Article ISSN 0278-5846

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